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EpinephrineBecause of the potential for promethazine to reverse epinephrine’s vasopressor effectepinephrine should NOT be used to treat hypotension associated with promethazine hydrochloride tablets overdose.
Promethazine suppositories are for rectal use onlyDo not try to swallow the suppositories or insert in any other part of your body.
AnticholinergicsConcomitant use of other agents with anticholinergic properties should be undertaken with cautionMonoamine Oxidase InhibitorsMAOIDrug interactionsincluding an increased incidence of extrapyramidal effectshave been reported when some MAOI and phenothiazines are used concomitantlyThis possibility should be considered with promethazine hydrochloride tablets.
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