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HYDREA may cause macrocytosiswhich is self-limitingand is often seen early in the course of treatmentThe morphologic change resembles pernicious anemiabut is not related to vitamin B12 or folic acid deficiencyThis may mask the diagnosis of pernicious anemiaProphylactic administration of folic acid is recommended.

Hydroxyurea is clastogenic in vitrohamster cellshuman lymphoblastsand in vivoSCE assay in rodentsmouse micronucleus assayHydroxyurea causes the transformation of rodent embryo cells to a tumorigenic phenotype.

Hydroxyurea is clastogenic in vitrohamster cellshuman lymphoblastsand in vivoSCE assay in rodentsmouse micronucleus assayHydroxyurea causes the transformation of rodent embryo cells to a tumorigenic phenotype.

Patients who have received irradiation therapy in the past may have an exacerbation of postirradiation erythemaMonitor for skin erythema in patients who previously received radiation and manage symptomatically.

Hydroxyurea may cause other cancerssuch as secondary leukemiaskin cancerProtect your skin from the sunAvoid prolonged sun exposuretanning boothsand sunlampsUse sunscreen and wear protective clothing when outdoorsTell your doctor right away if you notice any symptoms of cancersuch as swollen glandssudden weight lossnight sweatsor unusual skin growths/moles.

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