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Actiune terapeutica Acyclovirul este un analog sintetic de nucleozid puriniccu activitate inhibitorie in vivo si in vitro impotriva virusurilor herpetice umaneincluzind virusul herpes simplexhsvtip 1 si 2 si varicelo-zosterianVZVepstein barrEBVsi CitomegaliccmvIn culturi de celulezovirax are cea mai puternica activitate antivirala impotriva hsv-1fiind urmatain ordine descrescatoarede HSV-2VZVEBV si CMVActivitatea inhibitorie a zovirax pentru hsv-1HSV-2VZVEBV si CMV este inalt selectivaTimidinkinazaTKdin celulele normaleneinfectatenu foloseste zovirax ca substratastfel ca toxicitatea asupra celulelor gazda de mamifer este scazutatotusi TK codificata de hsvVZV si EBV transforma zovirax in acyclovir-monofosfatun analog nucleozidictransformat in continuare de enzimele celulare in difosfatsi in finalin trifosfatAcyclovir-trifosfat interfera cu ADN-polimeraza virala si inhiba replicarea ADN-ului viral cu intreruperea lantului in urma incorporarii in ADN-ul viralCure prelungite sau repetate de Zovirax la pacientii imunodeprimati sever pot duce la selectarea unor specii virale cu sensibilitate redusacare pot sa nu mai raspunda la continuarea terapiei cu zoviraxCele mai multe prelevate cu sensibilitate redusa prezentau o relativa deficienta a TK viraleoricums-au raportat suse cu TK sau ADN-polimeraza alterateExpunerea in vitro a hsv la zovirax poate duce de asemenea la selectarea de suse cu sensibilitate redusarelatia dintre sensibilitatea hsv in vitro si raspunsul clinic la terapia cu zovirax este neclara.

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